Anthracyclines and the heart
نویسندگان
چکیده
منابع مشابه
Anthracyclines and the heart.
The anthracyclines are effective and widely used antineoplastic agents. They are used to treat many types of malignancy including acute lymphoblastic leukaemia.' Their introduction has considerably improved survival, especially in childhood cancers. Signs of cardiac toxicity may develop during, soon after or many years after a course of treatment. Early toxicity is dependent principally on the ...
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Since their discovery more than 50 years ago, anthracyclines have become the mainstay for the treatment of many cancers. However, anthracyclines are associated with a risk of heart failure, with the risk proportionate to the cumulative exposure; cardiac injury appears to occur with every dose, and cardiac-biopsy specimens obtained within hours after a single dose of an anthracycline (e.g. doxor...
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The anthracycline antibiotics have now been in use in curative chemotherapy protocols for over two decades. They are highly active against a wide range of haemopoietic and solid tumours in children and adults. Unfortunately, their antineoplastic use is limited by significant and irreversible cardiotoxicity, the full extent of which continues to emerge. As more children become long term survivor...
متن کاملO12: The Heart and the Brain: Stroke Induced Heart Damage
Cardiac diseases are common post-stroke and are associated with increased morbidity and mortality. One possible mechanism of acute cardiac injury is the neurogenic myocardial damage, where the cerebral injury is disturbing the normal sympathetic and parasympathetic neuronal outflow to the heart leading to cardiac damage including myocardial infarctions. The exact mechanism is not completely und...
متن کاملRadiotherapy and anthracyclines – cardiovascular toxicity
The subject of this paper is to analyze the impact of radiotherapy and anthracyclines on the cardiovascular system, based on a survey of contemporary literature. Currently, high efficiency of anticancer therapies has increased the rate of survival in patients treated for cancer. It should be emphasized, however, that these treatments damage not only the affected but also the healthy tissue. Con...
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ژورنال
عنوان ژورنال: Heart
سال: 1994
ISSN: 1355-6037
DOI: 10.1136/hrt.72.3.300-a